The reflection invariance problems in stereochemical nomenclature for absolute configuration

Abstract Genesis of chirality and its link to the origin life continue intrigue scientists. Chirality also plays an important role in medicine with advent chiral drugs consequent importance asymmetric synthesis. The configuration a molecule gets inverted mirror image, as is manifested by (i) sign specific rotation (ii) normally, through absolute configurational notation ( R / S ). While first parameter always true, second one, that image relationship configurations, called reflection variance, may not hold good. In this manuscript, we have highlighted examples molecules combinations central axial or planar where between configurations does hold. This invariance originates from CIP rule precedes . Similar can be observed P M forms conformations some particular ligands. Proposal avoid such invariances, has been put forward. An ignorance about possibility enantiomeric lead common mistakes stereoisomeric reactivity profile.